|
KMID : 0360419780140010041
|
|
Korean Journal of Pharmacology
1978 Volume.14 No. 1 p.41 ~ p.46
|
|
|
Pharmacological Effect of Cholates of Cardiac Function
|
|
|
|
|
Abstract
|
|
|
The effects of sodium taurocholate(STC) and sodium deoxycholate(SDC) on cardiac function were examined by using isolated atria of rabbit and guinea pig and heart of anesthetized frog. Also the antiarrythmic action of SDC and SDC on atrial arrhythmias induced by epinephrine or ouabain was studied.
The results were following.
The cholates exhibited a slight decrease in rate and contractile amplitude of the isolated rabbit atria. The cholates atolished partially the spontaneous arrhythmic occurring in isolated rabbit and guinea pig atria but no effect on the atrial arrhythmia induced by ouabain and epinephrine was observed. Concomitant administration of cholates with ouatain produced a marked prolongation of atrial arrhythmia in comparison to that of ouatain alone in both isolated rabbit and guinea pig atria. The cholates exhibited a marked prolongation in ventricular arrhythmia and cardiac arrest time in comparison to that of ouabain treatment. However, the combined treatment with cholates and ouabain produced a slight prolongation in comparison to that of ouabain alone in the heart of anesthetized frog.
The above results suggest that cholates have a slight antiarrythmic effect on the heart but this effectiveness is different from those of propranolol that is non-selective antiarrhythmic drug.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|